Katie was born in Queens, New York. Her stage debut was as Dorothy in The Wizard of Oz when she was in the fourth grade. She is a graduate of New York University, Tisch School of the Arts. At NYU, she starred in a mainstream play “Four Saints in Mexico” where she was noticed by her agent. Lowes has worked steady since she landed her first role in the Fox television series Rescue Me (2004). She had a regular role on the CW comedy drama Easy Money (2008-2009) as Brandy Buffkin. She has had steady guest star roles on many series including Private Practice (2010), Guiding Light (2005), NCIS (2007), Ghost Whisperer (2008), Grey’s Anatomy (2011) and As the World Turns (2004-2005). She has had several appearances in film as well including Transformer: Revenge of the Fallen (2009), Quarter Life Crisis (2006), and No Man’s Land: The Rise of Reeker (2008). She has starred in several independent films: The Job, Callers, Café, and Bear. In her most recent role, she played the role of Candlehead in the award winning animated film Wreck it Ralph (2012).
Lowes has achieved a great deal of success in the last few years and she knows that her struggle was not unique. She co-founded IAMA Theatre Company with Adam Shapiro in Los Angeles in 2007. IAMA consists of theatre artists from all over the United Staten seeking to connect and cultivate a new generation of audiences. Lowes married her friend and business partner Adam Shapiro in 2012.